Synovial intimal fibroblasts.

Synovial intimal fibroblasts.

Cells of the normal synovial intima fall into two clearly separable types, macrophages and fibroblasts.' 2 In diseased tissue separation on traditional criteria such as ultrastructure may be less clear cut, but recent studies using techniques for identifying specific gene products related to cell lineage suggest that this distinction remains valid.3 ' The fibroblasts of synovial intima have bee...

Synovial fibroblasts in 2017

Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their involvement in inflammation and cartilage destruction in rheumatoid arthritis (RA). Furthermore, epige...

Extracellular matrix of the synovial intimal cell layer.

Palisading cells of rheumatoid nodules: comparison with synovial intimal cells.

OBJECTIVES The palisading cells of rheumatoid nodules share certain features with synovial intimal cells. The similarities between the two cell populations have been reassessed using new cytochemical markers. METHODS Cell populations in cryostat sections of non-inflamed, rheumatoid and osteoarthritic synovial tissues, and rheumatoid nodules were assessed for the presence of CD68, prolyl hydro...

Microsatellite analysis in rheumatoid arthritis synovial fibroblasts.

OBJECTIVES Rheumatoid arthritis (RA) is a chronic disease characterised by irreversible destruction of the affected joints. As aggressive transformed-appearing synovial fibroblasts are commonly found at the site of invasion of the rheumatoid synovium into the adjacent cartilage and bone, the presence of microsatellite instability (MSI) and expression of mismatch repair enzymes as a possible mec...